サトウ　アツシ   佐藤　淳    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2020/09
形態種別	学術論文
査読	査読あり
標題	The pain-relieving effects of lactoferrin on oxaliplatin-induced neuropathic pain
執筆形態	共著
掲載誌名	The Journal of Veterinary Medical Science
掲載区分	国内
出版社・発行元	Japanese Society of Veterinary Science
巻・号・頁	82(11),pp.1648-1654
著者・共著者	Takeshi FUJIMURA, Aiko IGUCHI, Atsushi SATO, Shinji KAGAYA, Tatsuo HOSHINO, Takashi TAKEUCHI
概要	Oxaliplatin (OXL) therapy often causes side effects including chronic peripheral neuropathy. We investigated the pain-relieving effects of recombinant human lactoferrin (rhLf) as well as a long-acting IgG-Fc fused rhLf (rhLf-Fc) on OXL-induced neuropathic pain. We used the hLf in this study, because the homology between mouse Lf and hLf is higher than that of bovine Lf. In addition, rhLf-Fc is expected to enhance the analgesic effect due to the life extension effect in the body. We administered OXL (2 mg/kg, i.v.) to mice twice weekly for 4 weeks. Phosphate buffered saline (PBS), rhLf (100 mg/kg, i.p.) or rhLf-Fc (100 mg/kg, i.p.) was administered once a week from day 15 to 32. We also assessed the continuous infusion of same drugs (10 mg/kg/day) into the external jugular vein by using an osmotic pump. Both of rhLf and rhLf-Fc significantly reduced the hypersensitivity to mechanical stimulation when they were administered intraperitoneally. The continuous infusion of rhLf resulted in a more pronounced effect. Histopathological analysis of sciatic nerve showed that both rhLf and rhLf-Fc tended to reduce nerve fiber damage, but no significant difference was observed in nerve fiber cross-sectional area. Therefore, it was suggested that rhLf or rhLf-Fc injection could be an option for controlling neuropathic pain, which are side effects of OXL.
外部リンクURL	https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_20-0034/_article