ニシ　リョウタロウ   西　良太郎    所属   応用生物学部 応用生物学科    職種   准教授
言語種別	英語
発行・発表の年月	2017/07
形態種別	学術論文
査読	査読あり
招待論文	招待あり
標題	Balancing act: To be, or not to be ubiquitylated.
執筆形態	単著
掲載誌名	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
掲載区分	国外
出版社・発行元	ELSEVIER
巻・号・頁	803-805,pp.43-50
総ページ数	8
担当区分	筆頭著者,最終著者,責任著者
著者・共著者	Ryotaro Nishi
概要	DNA double-strand breaks (DSBs) are one of the most deleterious DNA lesions. Appropriate repair of DSB either by homologous recombination or non-homologous end-joining is critical for maintaining genome stability and fitness. DSB repair cooperates with cellular signalling networks, namely DSB response (DDR), which plays pivotal roles in the choice of DSB repair pathway, orchestrating recruitment of DDR factors to site of damage, transcription suppression and cell cycle checkpoint activation. It has been revealed that these mechanisms are strictly regulated, in time and space, by complex and minute ubiquitylation-mediated reactions. Furthermore, balancing the ubiquitylation status of the DDR and DSB repair proteins by deubiquitylation, which is carried out by deubiquitylating enzymes (DUBs), is also found to be important. Recent findings have uncovered that DUBs are involved in various aspects of both DDR and DSB repair by counteracting non-proteolytic ubiquitylations in addition to protecting substrates from proteasomal degradation by removing proteolytic ubiquitylation. An advanced understanding of the detailed molecular mechanisms of the “balancing act” between ubiquitylation and deubiquitylation will provide novel therapeutic targets for diseases caused by dysfunction of DDR and DSB repair.
DOI	https://doi.org/10.1016/j.mrfmmm.2017.07.006
論文（査読付）ファイル	DOWNLOAD