フジタ　タカシ   藤田　隆史    所属   工学部 応用化学科    職種   助教
言語種別	英語
発行・発表の年月	2021/11
形態種別	学術論文
査読	査読あり
標題	Anti-inflammatory effect of gold nanoparticles supported on metal oxides
執筆形態	共著
掲載誌名	scientific reports
掲載区分	国外
出版社・発行元	nature portfolio
巻・号・頁	11,pp.23129
担当区分	筆頭著者
国際共著	国際共著
著者・共著者	Takashi Fujita, Maeva Zysman, Dan Elgrabli, Toru Murayama, Masatake Haruta, Sophie Lanone, Tamao Ishida, Jorge Boczkowski
概要	Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/CeO2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2 > Au/ZrO2 > Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3–8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx.