オギノ　ミノル   荻野　稔    所属   医療保健学部 臨床工学科    職種   准教授
言語種別	英語
発行・発表の年月	2018/12
形態種別	学術論文
査読	査読あり
標題	Preservation of hydrogen dissolved in hemofiltration replacement fluid and hydrogen permeability of kemofiltwation membranes
執筆形態	共著
掲載誌名	Journal of Society for Technology of Blood purification
掲載区分	国内
出版社・発行元	株式会社　春恒社
巻・号・頁	26(2),pp.151-160
総ページ数	10
著者・共著者	荻野稔、苗村潔、伊藤奈々、笠井亮佑、加納敬、上条史記、楠元直樹、秋本和哉、石川貴一、大脇杏実、西澤菜津子、田仲浩平、篠原一彦、横山憲二
概要	Introduction: Dialysis using hydrogen-dissolved solution has become an attractive method considering the oxidative stress suppression effects of hydrogen. Here, we focused on the use of hydrogen-dissolved solution for hemofiltration. We specifically evaluated the hydrogen-dissolved blood filtration replacement fluid preservation method and the hydrogen permeability of the hemofiltration membranes. To the best of our knowledge, this is the first report focusing on the hydrogen-dissolved hemofiltration replacement fluid. Methods: To define the shelf life of the hydrogen in solution, we assessed the influence of dissolved hydrogen concentration and the composition of the substitution solution stored at room temperature and under refrigeration. Moreover, we measured the hydrogen concentration of the water hemofiltration replacement fluid that passed through the hemofiltration membrane to assess the hydrogen permeability of the hemofiltration membrane using the hemofiltration simulation circuit. We compared three kinds of hemofiltration membranes: polymethyl methacrylate, sodium-acrylonitrile methallylsulfonate copolymer （AN 69 ST）, and polysulfone （PS） membrane. Findings: The residual hydrogen concentration of the hydrogen-dissolved hemofiltration replacement fluid stored for 4 weeks was 1% at room temperature（ 23 ± 3℃） and 19% at refrigeration（ 4℃） with respect to the initial value. No changes were observed in the composition concentration of hydrogen-dissolved blood filtration replacement fluid. Although all tested blood membrane filters demonstrated hydrogen permeability.
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