サトウ　タクミ   佐藤　拓己    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2323/08
形態種別	学術論文
査読	査読あり
標題	Prebiotic effect of poly-D-3-hydroxybutyrate prevents dyslipidemia in obese mice
執筆形態	共著
掲載誌名	FASEB journal
掲載区分	国外
出版社・発行元	FASEB
巻・号・頁	37(9),pp.e23131
総ページ数	12
著者・共著者	†Mayuko Mishima, Shiro Takeda, Masaki Nagane, Takehito Suzuki, Masaya Ogata, Ayaka Shima, Naoyuki Aihara, Junichi Kamiie, Rimina Suzuki, Hinano Mizugaki, Yuko Okamatsu-Ogura, Takumi Satoh, Tadashi Yamashita
概要	Obesity is a global health problem caused by genetic, environmental, and psychological factors and is associated with various health disorders. As such, there is a growing focus on the prevention of obesity and related diseases. The gut microbiota plays a crucial role in these diseases and has become a therapeutic target. Prebiotics, such as poly-D-3-hydroxybutyric acid (PHB), have gained attention for their potential to alter the gut microbiota, promote beneficial bacterial growth, and alleviate obesity. In this study, we examined the prebiotic effects of PHB in obese mice. We found that, in C57BL/6N mice, PHB reduced blood lipid levels. Analysis of the intestinal microflora also revealed an increase in short-chain fatty acid-producing bacteria. When PHB was administered to obese mice, subcutaneous fat and dyslipidemia were reduced, and the number of beneficial bacteria in the intestinal microflora increased. Furthermore, fatty degradation and oxidative stress were suppressed in the liver. PHB regulates gut bacterial changes related to obesity and effectively inhibits dyslipidemia, suggesting that it could be a prebiotic agent for curing various obesity-related diseases. In summary, PHB increases the beneficial gut microbiota, leading to an alleviation of obesity-associated dyslipidemia.
researchmap用URL	https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202301191R