マツイ　タケシ   Takeshi Matsui   松井　毅    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2023/11
形態種別	学術雑誌,解説・総説
査読	査読あり
招待論文	招待あり
標題	Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells
執筆形態	単著
掲載誌名	Journal of Developmental Biology
掲載区分	国外
出版社・発行元	MDPI
巻・号・頁	11(43),pp.1-11
総ページ数	11
担当区分	筆頭著者,責任著者
著者・共著者	Takeshi Matsui
概要	Epidermal development is responsible for the formation of the outermost layer of the skin, the epidermis. The establishment of the epidermal barrier is a critical aspect of mammalian development. Proper formation of the epidermis, which is composed of stratified squamous epithelial cells, is essential for the survival of terrestrial vertebrates because it acts as a crucial protective barrier against external threats such as pathogens, toxins, and physical trauma. In mammals, epidermal development begins from the embryonic surface ectoderm, which gives rise to the basal layer of the epidermis. This layer undergoes a series of complex processes that lead to the formation of subsequent layers, including the stratum intermedium, stratum spinosum, stratum granulosum, and stratum corneum. The stratum corneum, which is the topmost layer of the epidermis, is formed by corneoptosis, a specialized form of cell death. This process involves the transformation of epidermal keratinocytes in the granular layer into flattened dead cells, which constitute the protective barrier. In this review, we focus on the intricate mechanisms that drive the development and establishment of the mammalian epidermis to gain insight into the complex processes that govern this vital biological system.
DOI	doi.org/10.3390/jdb11040043
researchmap用URL	https://www.mdpi.com/2221-3759/11/4/43
外部リンクURL	https://www.mdpi.com/2221-3759/11/4/43