マツイ　タケシ   Takeshi Matsui   松井　毅    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2023/07
形態種別	学術論文
査読	査読あり
標題	Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice
執筆形態	共著
掲載誌名	Nature Communications
掲載区分	国外
出版社・発行元	SPRINGER NATURE
巻・号・頁	14,pp.4104
著者・共著者	Jing Lei, Reiko U. Yoshimoto, Takeshi Matsui, Masayuki Amagai, Mizuho A. Kido, Makoto Tominaga
概要	TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin keratinocytes, and it participates in various somatic processes. Although TRPV3 was suggested to be required for thermosensation, this interpretation is still controversial because of the lack of direct evidence. Here, we identified a transmembrane protein, TMEM79, that acts as a negative regulator of TRPV3. Heterologous expression of TMEM79 was capable of suppressing TRPV3-mediated currents in HEK293T cells. In addition, TMEM79 modulated TRPV3 translocalization and promoted its degradation in the lysosomes. TRPV3-mediated currents and Ca2+ influx were potentiated in primary mouse keratinocytes lacking TMEM79. Furthermore, TMEM79-deficient male mice preferred a higher temperature than did wild-type mice due to elevated TRPV3 function. Our study revealed a unique interaction between TRPV3 and TMEM79 in vitro and in vivo, which provided direct support for the underlying involvement of TRPV3 in thermosensation.
researchmap用URL	https://www.nature.com/articles/s41467-023-39712-x
外部リンクURL	https://www.nature.com/articles/s41467-023-39712-x