トモリ　コウノスケ   友利　幸之介    所属   医療保健学部 リハビリテーション学科　作業療法学専攻    職種   教授
言語種別	日本語
発行・発表の年月	2010
形態種別	学術論文
査読	査読あり
標題	Low-intensity electrical stimulation ameliorates disruption of transverse tubules and neuromuscular junctional architecture in denervated rat skeletal muscle fibers
執筆形態	共著
掲載誌名	J Muscle Res Cell Motil
掲載区分	国内
巻・号・頁	31,195-205頁
著者・共著者	Tomori K, Ohta Y, Nishizawa T, Tamaki H, Takekura H (IF 2.071)
概要	We determine the effects of direct electrical stimulation (ES) on the histological profiles in atrophied skeletal muscle fibers after denervation caused by nerve freezing. Direct ES was performed on the tibialis anterior (TA) muscle after denervation in rats divided into groups as follows: control (CON), denervation (DN), or denervation with direct ES (subdivided into a 4mA (ES4), an 8mA (ES8), or a 16mA stimulus (ES16)). The membrane disruptions seemed to be ameliorated by relatively low intensity ES (4mA and 8mA), and the area of longitudinally oriented t-tubules and the number of pentads and heptads decreased, and modified nerve terminals were seen in the NMJs in ES4 and ES8 compared to the DN. However, the highest intensity (16mA) did not improve the disruption of membrane systems and seen the modified NMJs. The relatively low-intensity ES ameliorates disruption of membrane system architecture in denervated skeletal muscle fibers, but that it is necessary to select the optimal stimulus intensities to preserve the structural integrity of denervated muscle fibers.