トモリ　コウノスケ   友利　幸之介    所属   医療保健学部 リハビリテーション学科　作業療法学専攻    職種   教授
言語種別	日本語
発行・発表の年月	2008
形態種別	学術論文
査読	査読あり
標題	Effect of neuromuscular electrical stimulation of denervation muscle on the mRNA expression of IGFs in rat skeletal muscle and sciatic nerve
執筆形態	共著
掲載誌名	J Phys. Ther.Sci
掲載区分	国内
巻・号・頁	21,269-273頁
著者・共著者	Tomori K, Kobayashi R, Koseki T, Ohta Y
概要	We determined the effect of neuromuscular electrical stimulation on expression of insulin-like growth factor-1 and 2, and their receptors' mRNA in skeletal denervated muscles and sciatic nerves of Wistar rats. The day following the denervation, the bilateral gastrocnemius muscles were electrically stimulated percutaneously, for 30 min/day at 4 mA intensity and 10 Hz frequency. After 3 weeks, the muscles and crushed site of the sciatic nerve were dissected. Relative muscle weights were decreased by denervation; however, the decrease was less after electrical stimulation. Expression of insulin-like growth factor-1 and 2 mRNA in denervated muscle and sciatic nerve were increased by electrical stimulation. Our results demonstrate that electrical stimulation retards muscle atrophy and promotes nerve regeneration following denervation by increasing insulin-like growth factors' mRNA in the denervated muscle.