ウエノ　サトシ   上野 聡    所属   工学部 応用化学科    職種   准教授
言語種別	英語
発行・発表の年月	2023/01
形態種別	学術論文
査読	査読あり
標題	One-Pot Synthesis of Substituted Pyridines from Alkyl Ketones and Enamines by the Nickel-Catalyzed Dehydrogenation of Alkyl Ketones
執筆形態	共著
掲載誌名	Chemistry Letters
掲載区分	国内
出版社・発行元	Chemical Society of Japan
巻・号・頁	3(52),pp.148-151
総ページ数	4
担当区分	筆頭著者,責任著者
著者・共著者	Satoshi Ueno, Ryohei Maeda, Yuya Kogure, and Ryoichi Kuwano
概要	The one-pot synthesis of substituted pyridines from alkyl ketones, Stork enamines, and ammonia is reported. This reaction involves the nickel-catalyzed dehydrogenation of the alkyl ketone and conjugate addition of the enamine, followed by condensation with an ammonium salt to yield the corresponding pyridine. Furthermore, the α-alkylation of δ-amino-γ,δ-unsaturated ketone intermediates leads to the synthesis of tetrasubstituted pyridine in excellent yields by means of a three-step one-pot reaction.
外部リンクURL	https://doi.org/10.1246/cl.220546