マツイ　タケシ   Takeshi Matsui   松井　毅    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2012
形態種別	著書
招待論文	招待あり
標題	Endogenous Retroviral-Like Aspartic Protease, SASPaseas a Key Modulator of Skin Moisturization
執筆形態	単著
掲載誌名	Treatment of Dry Skin Syndrome -The Art and Science of Moisturizers
掲載区分	国外
出版社・発行元	Springer (Edited by Lodén and Maibach)
巻・号・頁	Part2,pp.179-192
総ページ数	14
担当区分	筆頭著者,責任著者
著者・共著者	Takeshi Matsui
概要	The stratum corneum (SC) is hydrated by endogenous substances to avoid desiccation; however, the mechanisms responsible for maintaining hydration of the SC remain unclear. We have recently generated skin-specific retroviral-like aspartic protease (SASPase) deficient ‘hairless’ mice. The reduced activity of this enzyme in these mice results in dry skin with the accumulation of incorrectly processed profilaggrin and a marked decrease of filaggrin production. Several missense human mutations that affect the protease activity have been detected in both atopic dermatitis patients and normal individuals. Our results provide novel concepts to assist in determining the complex pathophysiology of atopic dry skin and provide clues in revealing the role of the SC in terrestrial animals and how they have adapted to life on land during the evolution of mammals.