ナカムラ　ヒデアキ   Hideaki Nakamura   中村　秀明    所属   学環 教養学環    職種   専任講師
言語種別	英語
発行・発表の年月	2025/05
形態種別	学術雑誌,解説・総説
査読	査読あり
招待論文	招待あり
標題	Whole Cells of Microorganisms—A Powerful Bioanalytical Tool for Measuring Integral Parameters of Pollution: A Review
執筆形態	共著
掲載誌名	Biosensors (in my Special Issue: Microbial Biosensor: From Design to Applications—2nd Edition)
掲載区分	国外
出版社・発行元	MDPI
巻・号・頁	15(5),pp.290
総ページ数	54
担当範囲	Project administration and Supervision
国際共著	国際共著
著者・共著者	Cheliukanov, M., Gurkin, G., Perchikov, R., Medvedeva, A., Lavrova, T., Belousova, T., Titova, A., Plekhanova, Y., Tarasov, S., Kharkova, A., Arlyapov, V., Mandin, P., Nakamura, H., & Reshetilov, A.
概要	Microbial biosensors are bioanalytical devices that can measure the toxicity of pollutants or detect specific substances. This is the greatest advantage of microbial biosensors which use whole cells of microorganisms as powerful tools for measuring integral parameters of environmental pollution. This review explores the core principles of microbial biosensors including biofuel devices, emphasizing their capacity to evaluate biochemical oxygen demand (BOD), toxicity, heavy metals, surfactants, phenols, pesticides, inorganic pollutants, and microbiological contamination. However, practical challenges, such as sensitivity to environmental factors like pH, salinity, and the presence of competing substances, continue to hinder their broader application and long-term stability. The performance of these biosensors is closely tied to both technological advancement and the scientific understanding of biological systems, which influence data interpretation and device optimization. The review further examines cutting-edge developments, including the integration of electroactive biofilms with nanomaterials, molecular biology techniques, and artificial intelligence, all of which significantly enhance biosensor functionality and analytical accuracy. Commercial implementations and improvement strategies are also discussed, providing a comprehensive overview of the state-of-the-art in this field. Overall, this work consolidates recent progress and identifies both the potential and limitations of microbial biosensors, offering valuable insights into their future development for environmental monitoring.
DOI	10.3390/bios15050290
外部リンクURL	https://www.mdpi.com/2079-6374/15/5/290