サトウ アツシ   Atsushi Sato   佐藤 淳    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2026/03
形態種別	学術論文
査読	査読あり
標題	Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin-albumin fusion
執筆形態	共著
掲載誌名	FEBS Open Bio
掲載区分	国外
出版社・発行元	John Wiley & Sons Ltd
担当区分	責任著者
著者・共著者	Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, and Atsushi Sato
概要	The fusion of human serum albumin with human lactoferrin (hLF-HSA) exerts strong anti-migratory effects in human lung adenocarcinoma cells through matrix metalloproteinase 1 (MMP1) downregulation. We demonstrate that hLF-HSA disrupts organelle pH homeostasis via Na+/H+ exchanger 7 (NHE7) upregulation, inducing organelle alkalization in the Golgi apparatus. This organelle dysfunction alters the Golgi-mediated secretome, leading to MMP1 downregulation and suppression of cell migration. hLF-HSA–induced MMP1 downregulation also reverses epithelial-mesenchymal transition (EMT), further suppressing migration. Additionally, hLF-HSA–driven activation of caveolae-mediated endocytosis (CavME) signaling downregulated MMP1 expression without NHE7 upregulation. These findings highlight that hLF-HSA–mediated disruption of organelle pH regulation and CavME activation represents a potential strategy to suppress cancer cell migration.
外部リンクURL	https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70237