サトウ アツシ   Atsushi Sato   佐藤 淳    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2023/09
形態種別	学術講演予稿集（学会、研究会を含む）
標題	The Fusion of Human Serum Albumin to Human Lactoferrin demonstrates its enhanced anti-migratory activities against cancer cells
執筆形態	共著
掲載誌名	ラクトフェリン2023
掲載区分	国内
出版社・発行元	アイ・ケイ　コーポレーション
巻・号・頁	pp.65-68
総ページ数	4
担当区分	責任著者
著者・共著者	Hana Nopia, Daisuke Kurimoto and Atsushi Sato
概要	We have reported that the fusion of human serum albumin (HSA) to human lactoferrin (hLF), referred to as hLF-HSA, exhibits enhanced anti-proliferative activities on cancer cells as compared to hLF (Ueda et al., Eur J Pharm Sci., 2020). However, its effects on cancer cell migration were unknown. Therefore, we investigated the anti-migratory effects of hLF-HSA on the migration of PC-14 cells, a human lung adenocarcinoma cancer cell line, using two widely used cell migration methods: in-vitro wound healing and Boyden chamber assays. Although hLF unexpectedly promoted cell migration, hLF-HSA exhibited full suppression of PC-14 cell migration.