サトウ　アツシ   佐藤　淳    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2022/03
形態種別	学術雑誌,解説・総説
査読	査読あり
標題	Glycan-binding Properties of Basic Whey Protein Lactoferrin and Its Application in Nerve Regenerative Medicine
執筆形態	共著
掲載誌名	Trends in Glycoscience and Glycotechnology
掲載区分	国外
出版社・発行元	FCCA(Forum: Carbohydrates Coming of Age)
巻・号・頁	34(198),pp.E1-E5
著者・共著者	Masao Nakamura and Atsushi Sato
概要	The basic whey protein lactoferrin (LF) is a glycosaminoglycan (GAG)-binding protein that plays a role in innate immunity and is expected to be a potential biopharmaceutical because of its diverse functions. LF binds to heparan sulfate, a type of GAG on the cell surface, and is involved in neuroprotective and anti-cancer activities. Recently, it was found that human LF (hLF) binds to chondroitin sulfate E (CS-E), which inhibits neuronal axon outgrowth and neutralizes CS-E-induced axon outgrowth inhibition. LFs are potential therapeutic targets for GAG-related diseases, such as cancer, neurodegenerative diseases, and infectious diseases. This article outlines the general properties of LF and discusses the binding properties of hLF to CS-E and its application.
外部リンクURL	https://www.jstage.jst.go.jp/article/tigg/34/198/34_1957.1E/_article