サトウ　タクミ   佐藤　拓己    所属   応用生物学部 応用生物学科    職種   教授
言語種別	日本語
発行・発表の年月	2023/12
形態種別	学術論文
査読	査読あり
標題	3-Hydroxybutyrate could serve as a principal energy substrate for human microbiota
執筆形態	共著
掲載誌名	Medical Hypotheses
掲載区分	国外
出版社・発行元	エルゼビア
巻・号・頁	182,111217頁
総ページ数	6
担当区分	筆頭著者
著者・共著者	佐藤拓己　佐々木健吾
概要	3-Hydroxybutyrate (3HB) is a ketone body present in the lumen of the large intestine. Although the circulatory system regulates 3HB at around 0.1 mM, its concentration in the gut lumen is about 0.3 mM, possibly due to its high production by the gut epithelial cells. The mitochondrial rate-limiting enzyme, 3-hydroxy-3-methylglutarylCoA synthase 2 (HMGCS2), is responsible for 3HB production and was highly expressed in the epithelial cells. Thus, maintaining HMGCS2 expression is crucial for supplying 3HB to the microbiota. Herein, we proposed that the microbiota consumes 3HB produced by the gut epithelial cells by creating a physiological positive shuttle system called “Ketone Body-Butyrate Shuttle” between the gut epithelial cells and microbiota. Its decline may lead to aging of the gut environment. This shuttle might aid the mammals and microbiota to survive severe starvation by using 3HB. In addition, we propose that poly-β-hydroxybutyrate (PHB), a ketone donor to microbiotas, may be a specific activator of the ketone body-butyrate shuttle since PHB can donate 3HB to microbiotas in the large intestine.
researchmap用URL	https://pdf.sciencedirectassets.com/272414/1-s2.0-S0306987723X00139/1-s2.0-S030698772300213X/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjECgaCXVzLWVhc3QtMSJGMEQCIBg%2Ba%2FzmKdYPlzo%2BqVDjmYYcRZaWT%2FUoQzHRKrGtEGp1AiABWJ8IoJvQj3CrsLXlmYbbqJIu0GNyXanLgFgN