サトウ　タクミ   佐藤　拓己    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2022/12
形態種別	学術論文
査読	査読あり
標題	The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells
執筆形態	共著
掲載誌名	FASEB journal
掲載区分	国外
出版社・発行元	Federation of American Societies for Experimental Biology
巻・号・頁	37(1)
総ページ数	14
著者・共著者	Rimina Suzuki, Mayuko Mishima, Masaki Nagane, Hinano Mizugaki, Takehito Suzuki, Mariko Komuro, Takuto Shimizu, Tomoki Fukuyama, Shiro Takeda, Masaya Ogata, Takayoshi Miyamoto, Naoyuki Aihara, Junichi Kamiie, Shinji Kamisuki, Hiroto Yokaryo, Tadashi Yamashita, Takumi Satoh
概要	Inflammatory bowel disease (IBD) is a chronic persistent intestinal disorder, with ulcerative colitis and Crohn's disease being the most common. However, the physio-pathological development of IBD is still unknown. Therefore, research on the etiology and treatment of IBD has been conducted using a variety of approaches. Short-chain fatty acids such as 3-hydroxybutyrate (3-HB) are known to have various physiological activities. In particular, the production of 3-HB by the intestinal microflora is associated with the suppression of various inflammatory diseases. In this study, we investigated whether poly-D-3-hydroxybutyric acid (PHB), a polyester of 3-HB, is degraded by intestinal microbiota and works as a slow-release agent of 3-HB. Further, we examined whether PHB suppresses the pathogenesis of IBD models. As long as a PHB diet increased 3-HB concentrations in the feces and blood, PHB suppressed weight loss and histological inflammation in a dextran sulfate sodium-induced IBD model. Furthermore, PHB increased the accumulation of regulatory T cells in the rectum without affecting T cells in the spleen. These results indicate that PHB has potential applications in treating diseases related to the intestinal microbiota as a sustained 3-HB donor. We show for the first time that biodegradable polyester exhibits intestinal bacteria-mediated bioactivity toward IBD. The use of bioplastics, which are essential materials for sustainable social development, represents a novel approach to diseases related to dysbiosis, including IBD.