カサイ　リョウスケ   Kasai Ryosuke   笠井　亮佑    所属   医療保健学部 臨床工学科    職種   専任講師
言語種別	英語
発行・発表の年月	2018/11
形態種別	学術論文
査読	査読あり
標題	Preservation of hydrogen dissolved in hemofiltration replacement fluid and hydrogen permeability of hemofiltration membranes
執筆形態	共著
掲載誌名	Japan Society of Blood Purification Technology
掲載区分	国内
出版社・発行元	Japan Society of Blood Purification Technology
巻・号・頁	26(2),pp.151-160
著者・共著者	Minoru Ogino, Kiyoshi Naemura, Nana Ito, Ryosuke Kasai, Takashi Kano, Fuminori Kamijyo, Naoki Kusumoto, Kazuya Akimoto, Kiichi Ishikawa, Ami Owaki, Natsuko Nishizawa, Kohei Tanaka, Kazuhiko Shinohara, Kenji Yokoyama
概要	Introduction: Dialysis using hydrogen-dissolved solution has become an attractive method considering the oxidative stress suppression effects of hydrogen. Here, we focused on the use of hydrogen-dissolved solution for hemofiltration. We specifically evaluated the hydrogen-dissolved blood filtration replacement fluid preservation method and the hydrogen permeability of the hemofiltration membranes. To the best of our knowledge, this is the first report focusing on the hydrogen-dissolved hemofiltration replacement fluid. Methods: To define the shelf life of the hydrogen in solution, we assessed the influence of dissolved hydrogen concentration and the composition of the substitution solution stored at room temperature and under refrigeration. Moreover, we measured the hydrogen concentration of the water hemofiltration replacement fluid that passed through the hemofiltration membrane to assess the hydrogen permeability of the hemofiltration membrane using the hemofiltration simulation circuit. We compared three kinds of hemofiltration membranes: polymethyl methacrylate, sodium-acrylonitrile methallylsulfonate copolymer （AN 69 ST）, and polysulfone （PS） membrane. Findings: The residual hydrogen concentration of the hydrogen-dissolved hemofiltration replacement fluid stored for 4 weeks was 1% at room temperature （23 ± 3℃） and 19% at refrigeration （4℃） with respect to the initial value. No changes were observed in the composition concentration of hydrogen-dissolved blood filtration replacement fluid. Although all tested blood membrane filters demonstrated hydrogen permeability.