サトウ　タクミ   佐藤　拓己    所属   応用生物学部 応用生物学科    職種   教授
言語種別	英語
発行・発表の年月	2015/01
形態種別	学術論文
査読	査読あり
標題	Zonarol, a sesquiterpene from the brown algae Dictyopteris undulata, provides neuroprotection by activating the Nrf2/ARE pathway
執筆形態	共著
掲載誌名	Biochemical and Biophysical Research Communications (BBRC)
出版社・発行元	Elsevier
巻・号・頁	457(4),pp.718-722
著者・共著者	Hiroya Shimizu, Tomoyuki Koyama, Sohsuke Yamada, Stuart A. Lipton, Takumi Satoh
概要	Seaweed-origin electrophilic compounds are proposed as a class of neuroprotective compounds that provide neuroprotection through activation of the Nrf2/ARE pathway. Electrophilic hydroquinones are of particular interest due to their ability to become electrophilic quinones upon auto-oxidation. Although many marine plants produce a variety of electrophilic compounds, the detailed mechanism of action of these compounds remain unknown. Here, we focused on the neuroprotective effects of zonarol (ZO), a para-hydroquinone-type pro-electrophilic compound from the brown algae Dictyopteris undulata. We show that ZO activates the Nrf2/ARE pathway, induces phase-2 enzymes, and protects neuronal cells from oxidative stress. ZO is the first example of a neuroprotective pro-electrophilic compound obtained from brown algae.
論文（査読付）ファイル	DOWNLOAD
外部リンクURL	http://www.sciencedirect.com/science/article/pii/S0006291X15000893